Conference Abstracts
55. Falqués-Costa T., Pilheden M., Zhang Q., Ahlgren L., Sturesson H., Rönnstrand L., Hyrenius-Wittsten A., Kazi J. U., Hagström-Andersson, A. K. Treatment is shaping clonal evolution and resistance patterns in murine kmt2a-rearranged leukemia with subclonal FLT3-N676K HemaSphere (2023) 7(S3):p e467631f (Abstract).
54. Falqués T., Pilheden M., Zhang Q., Ahlgren L., Sturesson H., Rönnstrand L., Hyrenius-Wittsten A., Kazi J. U., Hagström-Andersson, A. Treatment is Shaping Clonal Evolution and Resistance Patterns in Murine KMT2A-Rearranged Leukemia with Subclonal FLT3 N676K EHA Library. 325160; EP406 (Abstract).
53. Falqués T., Pilheden M., Zhang Q., Ahlgren L., Sturesson H., Rönnstrand L., Hyrenius-Wittsten A., Kazi J. U., Hagström-Andersson, A. Treatment Shapes Clonal Evolution and Resistance Patterns in Murine KMT2A-Rearranged Leukemia with Subclonal FLT3 N676K Blood (2021) 138(Supplement 1):3354 (Abstract).
52. Shah K. and Kazi J.U. (2019) Identification of a New Targeted Therapy for T-Cell Acute Lymphoblastic Leukemia and Studies on Its Mechanism of Action, Blood 134 (Supplement_1): 2752 (Abstract).
51. Asong M., Kazi J.U. and Rönnstrand L. (2019) FLT3 Is Sumoylated and Localizes to the Nucleus in Acute Myeloid Leukemia, Blood 134 (Supplement_1): 2733 (Abstract).
50. Shah K. and Kazi J.U. (2018) The role of P2RY14 in acute leukemia, Cancer Research 78 (13 Supplement): 4750 (Abstract).
49. Kazi J.U. and Rönnstrand L. (2018) The mutational status of residue Y842 in FLT3 predicts the drug response in acute myeloid leukemia, Cancer Research 78 (13 Supplement): 3499 (Abstract).
48. Kazi J.U. and Rönnstrand L. (2017) Oncogenic transformation of FLT3-ITD is partially dependent on tyrosine 842 in the activation loop, Cancer Research 77 (13 Supplement): 2371 (Abstract).
47. Marhäll A., Fischer T., Heidel F.H., Kazi J.U. and Rönnstrand L. (2017) Insertion mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the D835Y mutation in acute myeloid leukemia, Cancer Research 77 (13 Supplement): 2380 (Abstract).
46. Sun J., Thingholm T., Li T., Kazi J.U., Zhao H. and Rönnstrand L. (2017) Xkr5 negatively regulates KIT/D816V signaling, Cancer Research 77 (13 Supplement): 2372 (Abstract).
45. Moharram S.A., Rönnstrand L. and Kazi J.U. (2017) Src-like adaptor protein 2 negatively regulates FLT3 and KIT downstream signaling, Cancer Research 77 (13 Supplement):2364 (Abstract).
44. Gazi M., Moharram S.A., Marhäll A., Shah K. and Kazi J.U. (2017) Pediatric relapsed acute lymphoblastic leukemia patients display enrichment of the PI3K/mTOR pathway and respond to the dual PI3K/mTOR inhibitor PKI-587, Cancer Research 77 (13 Supplement): 325 (Abstract).
43. Nagaraj S.R.M., Kazi J.U. and Rönnstrand L. (2017) SRMS regulates normal and oncogenic KIT signaling, Cancer Research 77 (13 Supplement): 340 (Abstract).
42. Hyrenius-Wittsten A., Sturesson H., Walsh M.P., Hansson J., Kazi J.U., Pilheden M., Nance S., Gupta P., Song G., Zhang J., Ma J., Gruber T.A., Downing J.R. and Andersson A.K. (2016) Activating Mutations Are Potent Pro-Leukemic Mediators in Murine MLL-MLLT3 Leukemia That Cause Distinct Transcriptional Profiles, Blood 128 (22), 3918 (Abstract).
41. Kazi J.U. and Rönnstrand L. (2016) Tyrosine 842 Residue in the Activation Loop of FLT3-ITD Is Indispensable for Oncogenic Transformation, Blood 128 (22), 5161 (Abstract).
40. Phung B., Kazi J.U., Lundby A., Bergsteinsdottir K., Sun J., Goding C.R., Jonsson G., Olsen J.V., Steingrimsson E., Rönnstrand L. (2016) KIT/D816V induces SRC-mediated tyrosine phosphorylation of MITF and altered transcription program in melanoma, Cancer Research 76 (14 Supplement), 1127 (Abstract).
39. Moharram S.A., Kazi J.U. and Rönnstrand L. (2016) Loss of Src-like Adaptor Protein 2 Expression Increases the Transforming Potential of Oncogenic FLT3-ITD, Blood 128 (22), 51o6 (Abstract).
38. Marhäll A., Fischer T., Heidel F.H., Kazi J.U. and Rönnstrand L. (2016) Internal Tandem Duplication (ITD) in the Tyrosine Kinase Domain of FLT3 Displays Higher Oncogenic Potential in Acute Myeloid Leukemia, Blood 128 (22), 5118 (Abstract).
37. Lindblad O., Cordero E., Puissant A., Macaulay L., Kabir N.N., Sun J., Haraldsson K., Borg Å., Levander F., Stegmaier K., Pietras K., Rönnstrand L., Kazi J.U. (2016) Mechanism of sorafenib resistance in acute myeloid leukemia. Cancer Research 76(14 Supplement): 310 (Abstract).
36. Chougule R.A., Kazi J.U. and Rönnstrand L. (2016) FYN expression potentiates FLT3-ITD-induced mitogenic signaling in acute myeloid leukemia, Cancer Research 76(14 Supplement): 1135 (Abstract).
35. Lindblad O., Cordero E., Puissant A., Macaulay L., Kabir N.N., Sun J., Haraldsson K., Borg Å., Levander F., Stegmaier K., Pietras K., Rönnstrand L. and Kazi J.U. (2015) Aberrant Activation of the PI3K/mTOR Pathway Promotes Resistance to Sorafenib in AML, Blood 126(23):2472 (Abstract).
34. Kazi J. U., Sun J. and Ronnstrand L. (2015) Phosphorylation of SLAP by the KIT-D816V oncogenic mutant suppresses SLAP-mediated negative regulation of KIT signaling, Cancer Research 75(15 Supplement): 4997 (Link, Abstract).
33. Agarwal S., Kazi J. U., Mohlin S., Påhlman S., and Ronnstrand L. (2015) Tyrosine 823 in the activation loop of c-Kit regulates the transforming capacity of the oncogenic mutant D816V and its sensitivity to kinase inhibitors, Cancer Research 75(15 Supplement): 128 (Link, Abstract).
32. Kazi J. U., Sun J. and Ronnstrand L. (2014) An oncogenic c-KIT mutant can bypass SLAP-mediated negative regulation by phosphorylating SLAP, Poster, 2014 ASCB/IFCB meeting, Philadelphia, PA (Link).
31. Kazi J. U., Agarwal S., Sun J., Bracco E. and Ronnstrand L. (2013) Adaptor protein SLAP differentially regulates normal and oncogenic c-Kit signaling in mastocytosis, Poster, 2013 ASCB ANNUAL MEETING, New Orleans, LA (Link).
30. Sun J., Kazi J.U. and Ronnstrand L. (2013) Non-lipid kinase activity of PI3-kinase isoform p110 delta is essential for the D816V mutation of c-Kit induced cell transformation, Poster, 2013 ASCB ANNUAL MEETING, New Orleans, LA (Link).
29. Kazi J. U., Vaapil M., Agarwal S., Bracco E., Påhlman S. and Ronnstrand L. (2013) Csk interacts with FLT3 and KIT receptors and regulates downstream signaling, Poster, Posttranslational Modification Networks (Link).
28. Kazi J. U., Vaapil M., Agarwal S., Bracco E., Påhlman S. and Ronnstrand L. (2013) The tyrosine kinase Csk associates with FLT3 and KIT receptors and regulates downstream signaling in acute myeloid leukemia, Poster, 18th Congress of European Hematology Association (Link).
27. Kazi J. U. and Ronnstrand L. (2013) Leukemic FLT3 signals via Grb10 and elevated Grb10 expression correlates with poor prognosis in acute myeloid leukemia, Cancer Research 73(8 Supplement): 4121 (Link, Abstract).
26. Lin D., Yin T.,Koren-Michowitz M., Ding L.W., Gueller S., Gery S., Tabayashi T., Bergholz U., Kazi J.U., Rönnstrand L., Stocking C. and Koeffler P. (2012) Adaptor Protein Lnk Binds to and Inhibits Normal and Leukemic FLT3, Blood 120(21):1312 (Link, Abstract).
25. Kazi J. U. and Ronnstrand L. (2012) Grb10 associates with Flt3 and regulates downstream signaling, Poster, PTMs in Cell Signaling (Link).
24. Kazi J. U. and Ronnstrand L. (2012) Adaptor protein Grb10 interacts with Flt3 and mediates aberrant hematopoietic cell proliferation induced by oncogenic Flt3-ITD mutant, Poster, EMBO Cellular Signaling & Molecular Medicine (Link).
23. Kazi J. U., Sun J. Ronnstrand L. (2010). The suppressors of cytokine signaling (SOCS) 2 and 6 interact with Flt3 in a phosphorylation dependent manner, Poster, Blood and defense retreat (Link).
22. Sohel R.M., Kazi J. U., Karmacharya M. B. and Soh J. W. (2010). Comparison of murine and human phosphatome identifies three protein folds in protein phosphatase catalytic domains, Poster, The 2010 KSBMB Annual Meeting, Q-19-07, P-419 (Link).
21. Kazi J. U., Kabir N. N. and Soh J. W. (2009). Identification and analysis of protein phosphatase: a structural approach, Poster, The 66th KSBMB Annual Meeting, R-13-08, P-305 (Link).
20. Kwon W. J., Kazi J. U. and Soh J. W. (2009). Sub-cellular localization of DAG-responsive PKC isoforms in HeLa cells, Poster, The 66th KSBMB Annual Meeting, I-12-12, P-236 (Link).
19. Kazi J. U. and Soh J. W. (2008). Bioinformatic analysis of the rat genome, Poster, The 48th Annual Meeting of the American Society for Cell Biology, 1263, B473, P-88, Mol Biol Cell 19 (suppl), abstract 1263 (Link).
18. Kim C. R., Kazi J. U., and Soh J. W. (2008). Construction and visualization of GFP-tyrosinase in mouse cells, Poster, The 48th Annual Meeting of the American Society for Cell Biology, San Francisco, California, S-L12, P-19, Mol Biol Cell 19 (suppl), abstract L12 (Link).
17. Kazi J. U. and Soh J. W. (2008). Eukaryotic protein kinases in the rat genome: Identification and comparative studies, Poster, The 102th National Meeting of the Korean Chemical Society, I 33P196, P-33 (Link).
16. Kim C. R., Kazi J. U., and Soh J. W. (2008). Expression and functional characterization of recombinant PKC isoforms using MBP fusion expression system, Poster, The 65th KSBMB Annual Meeting & KSMBMB-KSBMB joint symposium, N-18, P-264 (Link).
15. Kazi J. U., Kabir N. N. and Soh J. W. (2008). Identification and comparative genomics of the rat protein kinases, Poster, The 65th KSBMB Annual Meeting & KSMBMB-KSBMB joint symposium, R-10, P-317 (Link).
14. Kim C. R., Kazi J. U., and Soh J. W. (2008). Expression and purification of dominant negative protein kinase C isoforms using MBP fusion expression system, Poster, The 101th National Meeting of the Korean Chemical Society, II 31P45, P-386 (Link).
13. Kazi J. U. and Soh J. W. (2008). Identification and analysis of protein kinases in the rat genome, Poster, The 101th National Meeting of the Korean Chemical Society, II 31P46, P-386 (Link).
12. Kazi J. U., Weinstein I. B. and Soh J. W. (2007). Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G, Poster, Molecular Targets and Cancer Therapeutics, AACR-NCI-EORTC international Conference, C255, P-338, San Francisco, California (Link).
11. Park D. S., Kazi J. U., Kabir N. N., Karmacharya M. B., Khan M. M. and Soh J. W. (2007). Expression and functional characterization of recombinant PKC isoforms, Poster, 19th FAOBMB Seoul Conference, Korean Society for Biochemistry and Molecular Biology, G-87, P-332 (Link).
10. Kazi J. U., Park D. S., Kabir N. N., Karmacharya M. B., Khan M. M. and Soh J. W. (2007). Isoform-specific subcellular localization of protein kinase C isoforms in NIH3T3 cells, Poster, 19th FAOBMB Seoul Conference, Korean Society for Biochemistry and Molecular Biology, G-61, P-328 (Link).
9. Kazi J. U., Jang J. I., Kwon H. M., Park D. S. and Soh J. W. (2006). Cooperation between the Phorbol Ester TPA and c-H-ras in Induction of the Nuclear Proto-oncogene c-fos, Poster, The 46th Annual Meeting of the American Society for Cell Biology, 1427, B3, P-129, Mol Biol Cell 17 (suppl), abstract 1427, San Diego, California (Link).
8. Jang J. I., Lee Y. J., Kwon H. M., Park D. S., Kazi J. U., Lee Y. S. and Soh J. W. (2006). Autophosphorlyation-deficient Mutant of Protein Kinase C delta has Higher Kinase Activity and Apoptosis Activity than Protein Kinase C delta Wild Type, Poster, The 46th Annual Meeting of the American Society for Cell Biology, 91, B31, P-48, Mol Biol Cell 17 (suppl), abstract 91, San Diego, California (Link).
7. Kazi J. U., Park D. S., Jang J. I., Kwon H. M. and Soh J. W. (2006). Synergy between TPA and c-H-ras in c-fos induction, Poster, The 98th National Meeting of the Korean Chemical Society, II 28P269, P-325 (Link).
6. Park D. S., Kazi J. U. , Jang J. I., Kwon H. M. and Soh J. W. (2006). Expression and purification of PKC-REG mutants using 6xHis tag bacterial expression vector, Poster, The 98th National Meeting of the Korean Chemical Society, II 28P268, P-324 (Link).
5. Kwon H. M., Jang J. I., Kazi J. U., Park D. S. and Soh J. W. (2006). Role of PKC isoforms in beta-catenin-mediated cyclin D1 transcription in human colon cancer, Poster, The 98th National Meeting of the Korean Chemical Society, II 28P266, P-324 (Link).
4. Jang J. I., Kwon H. M., Park D. S., Kazi J. U. and Soh J. W. (2006). Celecoxib-induced growth inhibition inSW480 colon cancer cells is associated with activation of protein kinase G, Poster, The 98th National Meeting of the Korean Chemical Society, II 28P283, P-329 (Link).
3. Kazi J. U., Park D. S., Jang J. I., Kwon H. M. and Soh J. W. (2006). Expression and purification of dominant negative protein kinase C isoforms using GST fusion expression system, Poster, The 97th National Meeting of the Korean Chemical Society, I 31P275, P-337 (Link).
2. Park D. S., Kazi J. U. , Jang J. I., Kwon H. M. and Soh J. W. (2006). Expression and purification of protein kinase C isoforms using 6xHis tag bacterial expression vector, Poster, The 97th National Meeting of the Korean Chemical Society, I 31P277, P-337 (Link).
1. Kwon H. M., Jang J. I., Kazi J. U., Park D. S. and Soh J. W. (2006). Expression and purification of GST-PKC fusion protein, Poster, The 97th National Meeting of the Korean Chemical Society, I 31P278, P-338 (Link).