Publications

2018

Hyrenius-Wittsten A., Pilheden M., Sturesson H., Hansson J., Walsh M. P., Song G., Kazi J.U., Liu J., Ramakrishan R., Garcia-Ruiz C., Nance S., Gupta P., Zhang J., Rönnstrand L., Hultquist A., Downing J. R., Lindkvist-Petersson K., Paulsson K., Järås M., Gruber T. A., Ma J., and Andersson-Hagström A. K. (2018) De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia. Nature Communications 9(1): 1770 (Pubmed,  Link, Lund University, ResearchGate).

Rupar K., Moharram S.A., Kazi J.U. and Rönnstrand L (2018) Src-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation. Scientific Reports 8(1): 6405 (PubmedLinkLund UniversityResearchGate).

 

2017

Moharram S.A., Shah K. and Kazi J.U. (2017) T-cell acute lymphoblastic leukemia cells display activation of different survival pathways. Journal of Cancer 8(19): 4124-4129 (PubmedLinkLund UniversityResearchGate).

Marhäll A., Kazi J.U. and Rönnstrand L. (2017) The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation. Scientific Reports7(1): 13734 (PubmedLinkLund UniversityResearchGate).

Moharram S.A., Shah K., Khanum F., Marhäll A., Gazi M. and Kazi J.U. (2017) Efficacy of the CDK inhibitor dinaciclib in vitro and in vivo in T-cell acute lymphoblastic leukemia. Cancer Letters 405(1): 73-78 (PubmedLinkLund UniversityResearchGate).

Phung B., Kazi J.U., Lundby A., Bergsteinsdottir K., Sun J., Goding C.R., Jönsson G., Olsen J. V., Steingrimsson E., and Rönnstrand L. (2017) KITD816V induces SRC-mediated tyrosine phosphorylation of MITF and altered transcription program in melanoma. Molecular Cancer Research15(9): 1265-1274 (PubmedLinkLund UniversityResearchGate).

Kazi J.U., Chougule R.A., Li T., Su X., Moharram S.A., Rupar K., Marhäll A., Gazi M., Sun J., Zhao H. and Rönnstrand L. (2017) Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD. Cellular and Molecular Life Sciences74(14): 2679–2688 (PubmedLinkLund UniversityResearchGate).

Gazi M., Moharram S.A., Marhäll A. and Kazi J.U. (2017) The dual specificity PI3K/mTOR inhibitor PKI-587 displays efficacy against T-cell acute lymphoblastic leukemia (T-ALL). Cancer Letters 392(1): 9-16 (Pubmed, LinkLund University, ResearchGate).

Kazi J.U., Rupar K., Marhäll A., Moharram S.A., Khanum F., Shah K., Gazi M., Nagaraj S.R., Sun J., Chougule R.A. and Rönnstrand L. (2017) ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling. Oncotarget8(7): 12194-12202 (PubmedLinkLund UniversityResearchGate).

Kazi J.U., Kabir N.N., and Rönnstrand L. (2017) BEX3. Encyclopedia of Signaling Molecule, Second Edition, Springer New York. 1-4, DOI: 10.1007/978-1-4614-6438-9_101775-1Book Chapter.

 

2016

Ke H., Kazi J.U., Zhao H., and Sun J. (2016) Germline mutations of KIT in gastrointestinal stromal tumor (GIST) and mastocytosis. Cell & Bioscience 6(66): 1-10 (PubmedLinkLund UniversityResearchGate) Review.

Moharram S.A., Chougule R.A.,  Su X., Li T., Sun J., Zhao H., Rönnstrand L. and Kazi J.U.(2016) Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling. Oncotarget 7(36): 57770-82 (Pubmed, Link, Lund University, ResearchGate).

Lindblad O., Cordero E., Puissant A., Macaulay L., Ramos A., Kabir N.N., Sun J., Vallon-Christersson J., Haraldsson K., Hemann M.T., Borg Å, Levander F., Stegmaier K., Pietras K., Rönnstrand L. and Kazi J.U. (2016) Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML. Oncogene (2016) 35(39): 5119-31 (PubmedLinkLund UniversityResearchGate).

Chougule R.A., Cordero E., Moharram S.A., Pietras K., Rönnstrand L. and Kazi J.U. (2016) Expression of GADS enhances FLT3-induced mitogenic signaling. Oncotarget 7(12): 14112-24 (PubmedLinkLund UniversityResearchGate).

Alam M.W., Persson C.U., Reinbothe S., Kazi J.U., Rönnstrand L., Wigerup C., Ditzel H.J., Lykkesfeldt A.E., Påhlman S. and Jögi A.  (2016) HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells. Oncotarget 7(10): 11238-50 (PubmedLinkLund UniversityResearchGate).

Chougule R.A., Kazi J.U. and Rönnstrand L. (2016) FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia. Oncotarget 7(9): 9964-74 (PubmedLinkLund UniversityResearchGate).

Kazi J.U., Moharram S.A., and Rönnstrand L. (2016) FMS-like Tyrosine Kinase-3. Encyclopedia of Signaling Molecule, Second Edition, Springer New York. 1-4, DOI: 10.1007/978-1-4614-6438-9_101667-1 Book Chapter.

Moharram S.A., Rönnstrand L. and Kazi J.U. (2016) Src-Like Adapter Protein 2 (SLAP2). Encyclopedia of Signaling Molecule, Second Edition, Springer New York. 1-4, DOI: 10.1007/978-1-4614-6438-9_101669-1 Book Chapter.

Rupar K., Kazi J.U., and Rönnstrand L. (2016) KIT. Encyclopedia of Signaling Molecule, Second Edition, Springer New York. 1-5, DOI: 10.1007/978-1-4614-6438-9_101666-1 Book Chapter.

Moharram S.A., Rönnstrand L. and Kazi J.U. (2016) Src-Like Adapter Protein (SLAP). Encyclopedia of Signaling Molecule, Second Edition, Springer New York. 1-4, DOI: 10.1007/978-1-4614-6438-9_101668-1 Book Chapter.

Kazi J.U., Kabir N.N., and Rönnstrand L. (2016) GRB10. Encyclopedia of Signaling Molecule, Second Edition, Springer New York. 1-4, DOI: 10.1007/978-1-4614-6438-9_101665-1 Book Chapter.

 

2015

Kazi J.U., Kabir N.N., and Rönnstrand L. (2015) Brain-Expressed X-linked (BEX) proteins in human cancers. Biochimica et Biophysica Acta (BBA) – Reviews on Cancer 1856(2): 226-233  (PubmedLinkLund UniversityResearchGate) Review.

Lindblad O., Chougule R.A., Moharram S.A., Kabir N.N., Sun J., Kazi J.U. and Rönnstrand L. (2015) The role of HOXB2 and HOXB3 in acute myeloid leukemia. Biochemical and Biophysical Research Communications 467(4): 742-747  (Pubmed, Link, Lund University, ResearchGate).

Zhang J., Vakhrusheva O., Bandi S. R., Demirel Ö., Kazi J.U., Fernandes R.G., Jakobi K., Eichler A., Rönnstrand L., Carpino N., Serve H. and Brandts C. H. (2015) The phosphatases STS1 and STS2 regulate hematopoietic stem and progenitor cell fitness. Stem Cell Reports5(4): 633-646 (Pubmed, Link, Lund University, ResearchGate).

Lindblad O., Kazi J.U., Rönnstrand L. and Sun J. (2015) PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase independent manner. Cellular and Molecular Life Sciences 72(22): 4399-4407 (PubmedLink, Lund University, ResearchGate).

Lindblad O., Li T., Su X., Sun J., Kabir N.N., Levander F., Zhao F., Lu G., Rönnstrand L. and Kazi J.U. (2015) BEX1 acts as a tumor suppressor in acute myeloid leukemia. Oncotarget6(25): 21395-21405  (PubMedLink, Lund UniversityResearchGate).

Agarwal S., Kazi J.U., Mohlin S., Påhlman S., and Rönnstrand L. (2015) The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V. Oncogene 34(35): 4581-4590 (PubMed, Link, Lund University, ResearchGate).

Kazi J.U., Nuzhat N.N. and Rönnstrand L. (2015) Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling. Cellular and Molecular Life Sciences 1856(2): 226-233 (PubmedLink, Lund University, ResearchGate) Review.

Kazi J.U., Kabir N.N., and Rönnstrand L. (2015) Drug Testing and Drug Development in Cell Culture. The SAGE Encyclopedia of Stem Cell Research, Second Edition, SAGE Publications, Inc. 363-366, DOI: 10.4135/9781483347660.n133 Book Chapter.

Kazi J.U., Sun J. and Rönnstrand L. (2015) Fluorescence-Activated Cell Sorting. The SAGE Encyclopedia of Stem Cell Research, Second Edition, SAGE Publications, Inc. 418-420, DOI: 10.4135/9781483347660.n153Book Chapter.

Lindblad O., Kazi J.U., Rönnstrand L. (2015) Bone marrow transplants. The SAGE Encyclopedia of Stem Cell Research, Second Edition, SAGE Publications, Inc. (2015) 129-132, DOI: 10.4135/9781483347660.n50 Book Chapter.

Kazi J.U., Flores-Morales A. and Rönnstrand L. (2015) SOCS6 (Suppressor Of Cytokine Signaling 6). Atlas of Genetics and Cytogenetics in Oncology and Haematology 19(1): 50-52 (LinkLund UniversityResearchGate) Book Chapter.

 

2014

Sun J., Mohlin S., Lundby A., Kazi J.U., Hellman U., Påhlman S., Olsen J. V. and Rönnstrand L. (2014) The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase independent manner. Oncogene 33(46): 5360-5369  (PubmedLink, Lund UniversityResearchGate).

Kabir N.N., Rönnstrand L. and Kazi J.U. (2014) Keratin 19 expression correlates with poor prognosis in breast cancer. Molecular Biology Reports41(12): 7729-7735 (PubmedLinkLund UniversityResearchGate).

Kabir N.N., Sun J., Rönnstrand L. and Kazi J.U. (2014) SOCS6 is a selective suppressor of receptor tyrosine kinase signaling. Tumor Biology 35(11): 10581-10589  (PubmedLink, Lund UniversityResearchGate) Review.

Kazi J.U., Kabir N.N., Flores-Morales A. and Rönnstrand L. (2014)SOCS proteins in regulation of receptor tyrosine kinase signaling. Cellular and Molecular Life Sciences, 71(17): 3297-3310 (PubmedLink, Lund UniversityResearchGateReview.

Puissant A, Fenouille N, Alexe G, Pikman Y, Bassil C.F., Mehta S, Du J, Kazi J.U., Luciano F, Rönnstrand L, Kung A.L., Aster J.C., Galinsky I., Stone R. M., DeAngelo D.J., Hemann M.T. and Stegmaier K (2014) SYK Is a Critical Regulator of FLT3 In Acute Myeloid Leukemia. Cancer Cell25 (2): 226-242  (PubmedLink, Lund University, ResearchGateComment, Comment, Comment).

Kazi J.U., Agarwal S., Sun J., Bracco E. and Rönnstrand L. (2014) Src-Like Adaptor Protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling. Journal of Cell Science 127(3): 653-662 (PubmedLink, Lund University, ResearchGate).

Kabir N.N. and Kazi J.U. (2014) Grb10 is a dual regulator of receptor tyrosine kinase signaling. Molecular Biology Reports41(4): 1985-1992 (PubmedLink, Lund University, ResearchGate) Review.

    

2013

Agarwal S., Kazi J.U. and Rönnstrand L. (2013) Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation. Journal of Biological Chemistry288(31): 22460-22468 (PubmedLink, Lund University, ResearchGate).

Kabir N.N., Rönnstrand L. and Kazi J.U. (2013) Protein Kinase C expression is deregulated in chronic lymphocytic leukemia. Leukemia and Lymphoma54(10): 2288-2290 (PubmedLinkLund UniversityResearchGateCommentary).

Kazi J.U., Vaapil M., Agarwal S., Bracco E., Påhlman S. and Rönnstrand L. (2013) The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling. Cellular Signalling 25(9): 1852-1860 (PubmedLinkLund University, ResearchGate).

Kazi J.U., Kabir N.N. and Rönnstrand L. (2013) Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia. Medical Oncology 30(4): 757, 1-8 (PubmedLink, Lund UniversityResearchGate) Review.

Kabir N.N., Rönnstrand L. and Kazi J.U. (2013) The basic helix-loop-helix (bHLH) proteins in breast cancer progression. Medical Oncology30(3): 666  (PubmedLinkLund UniversityResearchGate).

Kabir N.N., Rönnstrand L. and Kazi J.U. (2013) Deregulation of protein phosphatase expression in acute myeloid leukemia. Medical Oncology 30(2): 517 (PubmedLinkLund UniversityReaearchGate).

Kazi J.U., Sun J. and Rönnstrand L. (2013) The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome. Experimental Hematology 41(7): 585-587 (PubmedLinkLund UniversityResearchGate).

Kazi J.U. and Rönnstrand L. (2013) Suppressor of Cytokine Signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling. Molecular Oncology 7(3): 693-703 (PubmedLinkLund University, ResearchGate).

Kabir N.N., Rönnstrand L. and Kazi J.U. (2013) FLT3 mutations in patients with childhood acute lymphoblastic leukemia (ALL). Medical Oncology30(1): 462 (PubmedLinkLund UniversityResearchGate).

Kazi J.U. and Rönnstrand L. (2013) FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia. Molecular Oncology 7(3): 402-418 (PubmedLinkLund University, ResearchGate).

Kabir N.N. and Kazi J.U.(2013) Selective mutation in ATP-binding site reduces affinity of drug to the kinase: a possible mechanism of chemo-resistance. Medical Oncology 30(1): 448 (PubmedLinkLund UniversityResearchGate).

 

2012

Kazi J.U. and Rönnstrand L. (2012) Src-like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling. PLoS One7(12): e53509 (PubmedLinkLund University, ResearchGate).

Kazi J.U., Sun J., Phung B., Zadjali F., Flores-Morales A. and Rönnstrand L. (2012) Suppressor of Cytokine Signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated Tyr 591 and Tyr 919 of Flt3. Journal of Biological Chemistry 287(43): 36509-36517 (PubmedLinkLund University, ResearchGate).

Lin D.C., Yin T., Koren-Michowitz M., Ding L.W., Gueller S., Gery S., Tabayashi T., Bergholz U., Kazi J. U., Rönnstrand L., Stocking C. and Koeffler H. P. (2012) Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood120(16): 3310-3317 (Pubmed, Link, Lund UniversityResearchGate).

 

2011

Kabir N.N., Hossain M. I. and Kazi J.U. (2011) Comparative Studies on Human and Rat Basic Helix-loop-helix Proteins. Asian Journal of Biological Sciences 4(8): 601-608 (LinkLund UniversityResearchGate).

Khan M.M.G., Rydén A.M., Chowdhury M.S., Hasan M.A. and Kazi J.U. (2011) Maximum likelihood analysis of mammalian p53 indicates the presence of positively selected sites and higher tumorigenic mutations in purifying sites. Gene 483(1-2): 29-35 (Pubmed, Link, Lund UniversityResearchGate).

Kabir N.N. and Kazi J.U. (2011) Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity. Genetics and Molecular Biology 34(4): 587-591 (PubmedLinkLund UniversityResearchGate).

Kazi J.U. (2011) The mechanism of protein kinase C regulation. Frontiers in Biology6(4): 328-336 (Link, Lund UniversityResearchGate) Review.

 

2010

Kim H.J., Kazi J.U., Lee Y.R., Nguyen D.H., Lee H.B., Shin J.H., Soh J.W., Kim E.K. (2010) Visualization of the melanosome transfer-inhibition in a mouse epidermal cell co-culture model. International Journal of Molecular Medicine25(2): 249-253 (Pubmed, Link, Lund UniversityResearcgGate).

   

2009

Kazi J.U., Kim C.R. and Soh J.W. (2009) Subcellular localization of diacylglycerol-responsive protein kinase C isoforms in HeLa cells. Bulletin of the Korean Chemical Society30(9): 1981-1984 (Link, Lund UniversityResearchGate).

 

2008

Kazi J.U. and Soh J.W. (2008) Induction of the Nuclear Proto-Oncogene c-fos by the Phorbol Ester TPA and c-H-Ras. Molecules and Cells 26(5): 462-467 (Pubmed, LinkLund UniversityResearchGate).

Soh J.W., Kazi J.U., Li H., Thompson W.J. and Weinstein I.B. (2008) Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G. Molecular Carcinogenesis47(7): 519-525 (Pubmed, Link, Lund UniversityResearchGate).

Kazi J.U. and Soh J.W. (2008) Role of regulatory domain mutants of PKC isoforms in c-fos induction. Bulletin of the Korean Chemical Society29(1): 252-254  (LinkLund UniversityResearchGate).

Kazi J.U., Kabir N.N. and Soh J.W. (2008) Bioinformatic prediction and analysis of eukaryotic protein kinases in the rat genome. Gene410(1): 147-153  (Pubmed, Link, Lund UniversityResearchGate).

 

2007

Kazi J.U. and Soh J.W. (2007) Isoform-specific translocation of PKC isoforms in NIH3T3 cells by TPA. Biochemical and Biophysical Research Communications364(2): 231-237 (Pubmed, Link, Lund UniversityResearchGate).