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The laboratory is working on understanding the molecular mechanisms by which acute lymphoblastic leukemia cells survive extensive chemotherapy. We are engaged in several projects using a combination of genetic, bioinformatics and biochemical tools to analyze the functions of specific target proteins and their role in the pathogenesis of acute lymphoblastic leukemia. The goal of our research is to uncover the underlying mechanisms of therapy resistance and to develop less toxic, highly effective molecularly-targeted therapies against acute lymphoblastic leukemia. The lab is mainly focusing on childhood leukemia as this group of patients suffers from long-term side effect of the current therapies.

Read more about us @ Lund UniversityTranslational Cancer Research

 

RECENT PUBLICATIONS:

Li T., Deng Y., Shi Y., Tian R., Chen Y., Zou L., Kazi J.U., Rönnstrand L., Feng B., Chan S. O., Chan W. Y., Sun J. and Zhao H. (2018) Bruton’s tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma. Oncogene 37(47):6180-6194. (PubmedLinkLund UniversityResearchGate).

Shah K., Moharram S. A. and Kazi J.U. (2018) Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression. Clinical Epigenetics 10: 83  (PubmedLinkLund UniversityResearchGate).

Hyrenius-Wittsten A., Pilheden M., Sturesson H., Hansson J., Walsh M. P., Song G., Kazi J.U., Liu J., Ramakrishan R., Garcia-Ruiz C., Nance S., Gupta P., Zhang J., Rönnstrand L., Hultquist A., Downing J. R., Lindkvist-Petersson K., Paulsson K., Järås M., Gruber T. A., Ma J., and Andersson-Hagström A. K. (2018) De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia. Nature Communications 9(1): 1770 (Pubmed,  Link, Lund UniversityResearchGate).

Rupar K., Moharram S.A., Kazi J.U. and Rönnstrand L (2018) Src-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation. Scientific Reports 8(1): 6405 (PubmedLinkLund UniversityResearchGate).

 

OUR COLLABORATORS:

Rönnstrand Lab
Acrivon AB